This discovery challenges the conventional belief that HEV only affects liver cells. The development of this cell model provides a foundation for future research to further understand the neuropathogenic effects of HEV and potentially find ways to prevent or treat neurological disorders caused by these viruses.

To summarize, Hepatitis E viruses not only infect liver cells but can also infect nerve cells, leading to neurological disorders. The creation of a cell model has allowed researchers to observe the direct infection of nerve cells by HEV and the lack of an effective immune response. Further research in this area is crucial to uncover the mechanisms of HEV’s neurotropism and develop strategies for prevention and treatment.