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Stem Cells vs. Cortisone: Navigating Treatment Options for Bone-on-Bone Joint Pain






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When faced with the debilitating pain of bone-on-bone osteoarthritis in joints like the shoulder, traditional solutions such as cortisone shots and the more experimental path of regenerative injections, including stem cells and exosomes, present a complex array of choices. In this blog, we delve into the insights shared by Dr. David Guyer, a triple board-certified orthopedic surgeon and expert in sports medicine and regenerative medicine, who explores the pros and cons of these treatment options. While cortisone injections have been a longstanding option for pain relief, concerns about their impact on cartilage and bone health over time remain prevalent. On the other hand, regenerative therapies, though still considered experimental by the FDA, offer a potential avenue to delay invasive procedures like joint replacements. Whether you’re considering less conventional treatments or pondering surgical options, this blog aims to provide a comprehensive overview of what Dr. Guyer suggests as potential paths forward in managing your osteoarthritis journey.

Understanding Bone-on-Bone Osteoarthritis

Understanding osteoarthritis, particularly when it progresses to a bone-on-bone stage, is essential in determining the best treatment pathway. Osteoarthritis involves the degeneration of cartilage, the protective tissue at the ends of bones. When this cartilage wears away completely, the bones in the joint rub against each other, causing severe pain and reduced mobility. This condition often leads individuals to seek various treatment options, ranging from conservative measures to more invasive interventions.

The Role of Cortisone Injections

Cortisone injections have been a staple in managing osteoarthritis pain. These injections aim to reduce inflammation within the joint, providing temporary relief. Dr. David Guyer highlights that cortisone shots can offer significant pain reduction, delaying the need for surgery. However, there’s a critical caveat: repeated use of cortisone can accelerate cartilage deterioration and weaken structures like the rotator cuff tendons in the shoulder. This can complicate future surgical interventions. Hence, while cortisone might help manage immediate pain, it’s not a long-term solution and can potentially exacerbate joint health in the long term.

Exploring Regenerative Treatments

Regenerative medicine has emerged as a promising area for osteoarthritis treatment. Technologies such as stem cells and exosomes have been the subject of much discussion and research. Stem cells have the potential to regenerate tissues by developing into different types of cells that the body needs, including cartilage cells. Meanwhile, exosomes, which are nano-sized vesicles released by cells, can modulate inflammation and tissue regeneration in joints.

Dr. Guyer notes that while these regenerative treatments are still considered experimental by the FDA, they offer hope for those aiming to delay surgery. These therapies, however, are not guaranteed to restore a joint to its previous state before arthritis. The primary benefit may lie in pain relief and improved function, offering individuals a temporary respite from the challenges of bone-on-bone arthritis.

Comparing Treatment Options

Regenerative treatments may be more appealing than cortisone for several reasons:

  • Reduced Long-term Side Effects: Unlike cortisone, which can degrade joint health over time, regenerative treatments focus on improving the body’s natural healing processes.
  • Potential for Improved Functionality: Patients may experience better joint movement and reduced stiffness post-treatment.
  • Delay of Surgical Intervention: By potentially improving joint health and reducing pain, these treatments may postpone the need for joint replacement surgery.

Despite the potential benefits, it is paramount for patients to discuss these options thoroughly with their orthopedic surgeon. The effectiveness of regenerative therapies can vary based on individual factors such as the severity of the arthritis, overall health, and the specific joint affected.

Considering Additional Alternatives

Another non-invasive option sometimes considered is visco-supplementation, which involves injecting hyaluronic acid into the joint to improve lubrication. However, Dr. Guyer suggests that once osteoarthritis progresses to a bone-on-bone stage, such treatments may offer limited relief.

Guiding Questions for Patients

For patients navigating these choices, a few guiding questions can be helpful:

  • What are my goals for treatment? (Pain relief, improved mobility, delaying surgery)
  • How do I weigh the potential risks and benefits of cortisone vs. regenerative treatments?
  • What is the likelihood of regenerative therapies improving my specific condition?
  • Are there lifestyle changes (e.g., weight management, physical therapy) that could complement these treatments?

Dr. Guyer’s insights underscore the importance of a personalized approach in managing osteoarthritis. There’s no one-size-fits-all solution, and patients must weigh the pros and cons of each treatment option relative to their unique circumstances.

Staying Informed and Proactive

As a part of ongoing efforts to provide education on osteoarthritis, Dr. Guyer offers an eBook, “The Arthritis Solution,” which can be a valuable resource for individuals seeking information beyond traditional medical consultations. While regenerative therapies offer exciting possibilities, the decision to pursue these treatments should be made with careful consideration and professional guidance.

Ultimately, staying informed and proactive about one’s health is crucial. Whether exploring cortisone injections or the emerging world of regenerative medicine, understanding the potential impact of each option will empower patients to make informed decisions in collaboration with their healthcare providers.


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Dr José Cláudio Rangel MD - Brazil
Dr José Cláudio Rangel MD - Brazil
Professional with a deep background in occupational health, regulatory compliance, and the strategic development of digital health solutions. With extensive expertise in workplace safety evaluations, including developing specialized aptitude and inaptitude protocols for high-risk activities, José is also focused on integrating comprehensive health assessments tailored to the unique demands of various industries.

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