This approach shows promise in overcoming the natural defenses of glioblastoma cells and improving the effectiveness of immunotherapy. The exact mechanism behind this strategy is still being investigated, but initial findings suggest that molecular pathways and signaling cascades within the cells can be manipulated to achieve this outcome. Further research is needed to validate the effectiveness and safety of this method in preclinical models and human clinical trials. Additionally, exploring the combination of this approach with existing immunotherapeutic agents may lead to even greater outcomes in glioblastoma treatment. Despite the challenges, scientists are optimistic that this strategy represents a significant step forward in the fight against glioblastoma. Through the enhancement of immunotherapy, they hope to improve patient outcomes and ultimately find a cure for this devastating form of brain cancer.